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dc.contributor.authorGaupset, Robin
dc.contributor.authorEftang, Lars Lohne
dc.contributor.authorLangbach, Odd
dc.contributor.authorFridrich, Katrin
dc.contributor.authorBorthne, Arne Sigmund
dc.contributor.authorGeitung, Jonn Terje
dc.contributor.authorSuntharalingam, Sutharsan
dc.contributor.authorIgnjatovic, Dejan
dc.contributor.authorRøkke, Ola
dc.date.accessioned2019-08-09T06:37:34Z
dc.date.available2019-08-09T06:37:34Z
dc.date.issued2018-02
dc.identifier.citationGaupset, R., Eftang, L. L., Langbach, O., Fridrich, K., Borthne, A., Geitung, J. T., ... & Røkke, O. (2018). Improved Survival after Implementation of Multidisciplinary Team Meetings, Perioperative Chemotherapy, Extended Lymphnode Dissection and Laparoscopic Surgery in the Treatment of Advanced Gastric Cancer. Journal of Cancer Therapy, 9(2).en
dc.identifier.issn2151-1934
dc.identifier.urihttps://hdl.handle.net/10642/7430
dc.description.abstractAims: The treatment of gastric cancer has changed in the western countries during the last decade. This includes multidisciplinary team (MDT) meetings, perioperative chemotherapy, extended lymph node dissection, and laparoscopic surgery, all of which were gradually implemented at our department from 2008. The aim of the present study was to determine the effect of these changes on morbidity and survival. Material and Methods: 185 patients with gastric cancer were operated with curative intent from 2000 until 2016 in this retrospective, observational, follow-up study; 83 before implementation of modern principles in 2008 (period 1) and 102 were treated after 2008 (period 2). Results: The resection rate (94% vs 92.8%) and mortality rates (4.8% vs 2.9%) did not differ between the two periods. In period 2, 48 patients (47.1%), received neoadjuvant chemotherapy. In 36 patients (35.3%), laparoscopic surgery with D2 lymphadenectomy was performed. There was a significantly higher yield in the number of lymph nodes in period 2 compared to period 1 (14 vs 8, p < 0.001). This is also apparent between laparoscopic and open surgery in the second period (32 vs 10, p < 0.001). The five-year survival rate was significantly improved after the change in treatment principles with an estimated improvement from 30% to 40% between the periods (p = 0.033). Conclusion: The combined effect of MDT meetings, neoadjuvant chemotherapy, extended lymphnode dissection and laparoscopy has improved the prognosis of gastric cancer patients. KEYWORDS Gastric Cancer, Chemotherapy, Laparoscopy, Survival, D2 Lymphadenectomyen
dc.language.isoenen
dc.publisherScientific Research Publishingen
dc.relation.ispartofseriesJournal of Cancer Therapy;9(2)
dc.rightsAttribution 3.0 United States This is an open access article, originally published at https://doi.org/10.4236/jct.2018.92012en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectArtikkelen
dc.subjectVDP::Medisinske Fag: 700en
dc.titleImproved Survival after Implementation of Multidisciplinary Team Meetings, Perioperative Chemotherapy, Extended Lymphnode Dissection and Laparoscopic Surgery in the Treatment of Advances Gastric Canceren
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionpublishedVersionen
dc.identifier.doihttps://doi.org/10.4236/jct.2018.92012
dc.identifier.cristinID1634405


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Attribution 3.0 United States

This is an open access article, originally published at https://doi.org/10.4236/jct.2018.92012
Except where otherwise noted, this item's license is described as Attribution 3.0 United States This is an open access article, originally published at https://doi.org/10.4236/jct.2018.92012