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dc.contributor.authorHessen, Erik
dc.contributor.authorEckerström, Marie
dc.contributor.authorNordlund, Arto
dc.contributor.authorAlmdahl, Ina
dc.contributor.authorStålhammar, Jacob
dc.contributor.authorBjerke, Maria
dc.contributor.authorEckerström, Carl
dc.contributor.authorGöthlin, Mattias
dc.contributor.authorFladby, Tormod
dc.contributor.authorReinvang, Ivar
dc.contributor.authorWallin, Anders
dc.date.accessioned2019-07-12T08:44:21Z
dc.date.available2019-07-12T08:44:21Z
dc.date.issued2017-02-02
dc.identifier.citationHessen, E., Eckerström, M., Nordlund, A., Almdahl, I. S., Stålhammar, J., Bjerke, M., ... & Wallin, A. (2017). Subjective cognitive impairment is a predominantly benign condition in memory clinic patients followed for 6 years: The Gothenburg-Oslo MCI Study. Dementia and geriatric cognitive disorders extra, 7(1), 1-14.en
dc.identifier.issn1664-5464
dc.identifier.urihttps://hdl.handle.net/10642/7280
dc.description.abstractBackground/Aims: In the quest for prevention or treatment, there is a need to find early markers for preclinical dementia. This study observed memory clinic patients with subjective cognitive impairment (SCI) and normal cognitive function at baseline. The primary aim was to address SCI as a potential risk factor for cognitive decline. The secondary aim was to address a potential relation between (1) baseline cerebrospinal fluid biomarkers and (2) a decline in memory performance over the first 2 years of follow-up, with a possible cognitive decline after 6 years. Methods: Eighty-one patients (mean age 61 years) were recruited from university memory clinics and followed up for 6 years. Results: Eighty-six percent of the cohort remained cognitively stable or improved, 9% developed mild cognitive impairment, and only 5% (n = 4) developed dementia. Regression analysis revealed that low levels of Aβ42 at baseline and memory decline during the first 2 years predicted dementia. When combined, these variables were associated with a 50% risk of developing dementia. Conclusions: Cognitive stability for 86% of the cohort suggests that SCI is predominantly a benign condition with regard to neuropathology. The low number of individuals who developed dementia limits the generalizability of the results and discussion of progression factors.
en
dc.language.isoenen
dc.publisherKargeren
dc.relation.ispartofseriesDementia and Geriatric Cognitive Disorders Extra;7(1)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States The final, published version of this article is available at https://www.karger.com/Article/FullText/454676en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleSubjective cognitive impairment is a predominantly benign condition in memory clinic patients followed for 6 years: The Gothenburg-oslo MCI Studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionpublishedVersionen
dc.identifier.doihttps://doi.org/10.1159/000454676
dc.identifier.cristinID1490222


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Attribution-NonCommercial-NoDerivs 3.0 United States
The final, published version of this article is available at https://www.karger.com/Article/FullText/454676
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States The final, published version of this article is available at https://www.karger.com/Article/FullText/454676