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dc.contributor.authorBlach, Sarah
dc.contributor.authorZeuzem, Stefan
dc.contributor.authorManns, Michael
dc.contributor.authorAltraif, Ibrahim
dc.contributor.authorDuberg, Ann-Sofi
dc.contributor.authorMuljono, David H
dc.contributor.authorWaked, Imam
dc.contributor.authorAlavian, Seyed M
dc.contributor.authorLee, Mei-Hsuan
dc.contributor.authorNegro, Francesco
dc.contributor.authorAbaalkhail, Faisal
dc.contributor.authorAbdou, Ahmed
dc.contributor.authorAbdulla, Maheeba
dc.contributor.authorRached, Antoine Abou
dc.contributor.authorAho, Inka
dc.contributor.authorAkarca, Ulus
dc.contributor.authorGhazzawi, Imad Al
dc.contributor.authorKaabi, Saad Al
dc.contributor.authorLawati, Faryal Al
dc.contributor.authorNamaani, Khalid Al
dc.contributor.authorSerkal, Youssif Al
dc.contributor.authorAl-Busafi, Said A
dc.contributor.authorAl-Dabal, Layla
dc.contributor.authorAleman, Soo
dc.contributor.authorAlghamdi, Abdullah S
dc.contributor.authorAljumah, Abdulrahman A
dc.contributor.authorAl-Romaihi, Hamad E
dc.contributor.authorAndersson, Monique I
dc.contributor.authorArendt, Vic
dc.contributor.authorArkkila, Perttu
dc.contributor.authorAssiri, Abdullah M
dc.contributor.authorBaatarkhuu, Oidov
dc.contributor.authorBane, Abate
dc.contributor.authorBen-Ari, Ziv
dc.contributor.authorBergin, Colm
dc.contributor.authorBessone, Fernando
dc.contributor.authorBihl, Florian
dc.contributor.authorBizri, Abdul R
dc.contributor.authorBlachier, Martin
dc.contributor.authorBlasco, Antonio J
dc.contributor.authorMello, Carlos E Brandao
dc.contributor.authorBruggmann, Philip
dc.contributor.authorBrunton, Cheryl R
dc.contributor.authorCalinas, Filipe
dc.contributor.authorChan, Henry L Y
dc.contributor.authorChaudhry, Asad
dc.contributor.authorCheinquer, Hugo
dc.contributor.authorChen, Chien-Jen
dc.contributor.authorChien, Rong-Nan
dc.contributor.authorChoi, Moon Seok
dc.contributor.authorChristensen, Peer B
dc.contributor.authorChuang, Wan-Long
dc.contributor.authorChulanov, Vladimir
dc.contributor.authorCisneros, Laura
dc.contributor.authorClausen, Mette R
dc.contributor.authorCramp, Matthew E
dc.contributor.authorCraxi, Antonio
dc.contributor.authorCroes, Esther A
dc.contributor.authorDalgard, Olav
dc.date.accessioned2019-07-11T11:52:49Z
dc.date.available2019-07-11T11:52:49Z
dc.date.issued2017-03
dc.identifier.citationBlach, S., Zeuzem, S., Manns, M., Altraif, I., Duberg, A.-S., Muljono, D. H., . . . Razavi, H. (2017). Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. The Lancet Gastroenterology & Hepatology, 2(3), 161-176. doi:10.1016/s2468-1253(16)30181-9en
dc.identifier.issn2468-1253
dc.identifier.urihttps://hdl.handle.net/10642/7268
dc.description.abstractBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of—and expansion on—the 2014 analysis, which reported 80 million (95% CI 64–103) viraemic infections in 2013.Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11 342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data.Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insuffi cient data to create a model. The global prevalence of viraemic HCV is estimated to be 1·0% (95% uncertainty interval 0·8–1·1) in 2015, corresponding to 71·1 million (62·5–79·4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively).Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesThe Lancet Gastroenterology and Hepatology;2(3)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States This is a postprint version of an article originally published at https://doi.org/10.1016/S2468-1253(16)30181-9en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleGlobal prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionacceptedVersionen
dc.identifier.doihttps://doi.org/10.1016/S2468-1253(16)30181-9
dc.identifier.cristinID1555823


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Attribution-NonCommercial-NoDerivs 3.0 United States
This is a postprint version of an article originally published at https://doi.org/10.1016/S2468-1253(16)30181-9
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States This is a postprint version of an article originally published at https://doi.org/10.1016/S2468-1253(16)30181-9