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dc.contributor.authorVistad, Ingvild
dc.contributor.authorBjørge, Line
dc.contributor.authorPopova, Olesya
dc.contributor.authorFiane, Bent
dc.contributor.authorSachse, Kurt
dc.contributor.authorTjugum, Ivar Jostein
dc.contributor.authorSkrøppa, Siri
dc.contributor.authorBentzen, Anne Gry
dc.contributor.authorStokstad, Trine
dc.contributor.authorIversen, Grete Alræk
dc.contributor.authorSalvesen, Helga Birgitte
dc.contributor.authorKristensen, Gunnar S Balle
dc.contributor.authorDørum, Anne
dc.date.accessioned2019-07-11T09:24:59Z
dc.date.available2019-07-11T09:24:59Z
dc.date.issued2017-08-10
dc.identifier.citationVistad, I., Bjorge, L., Solheim, O., Fiane, B., Sachse, K., Tjugum, J., . . . Dorum, A. (2017). A national, prospective observational study of first recurrence after primary treatment for gynecological cancer in Norway. Acta Obstet Gynecol Scand, 96(10), 1162-1169. doi:10.1111/aogs.13199en
dc.identifier.issn0001-6349 
dc.identifier.urihttps://hdl.handle.net/10642/7265
dc.description.abstractINTRODUCTION: Gynecological cancer patients are routinely followed up for five years after primary treatment. However, the value of such follow up has been debated, as retrospective studies indicate that first recurrence is often symptomatic and occurs within two to three years of primary treatment. We prospectively investigated time to first recurrence, symptoms at recurrence, diagnostic procedures, and recurrence treatment in gynecological cancer patients after primary curative treatment. MATERIAL AND METHODS: Clinicians from 21 hospitals in Norway interviewed 680 patients with first recurrence of gynecological cancer (409 ovarian, 213 uterine, and 58 cervical cancer patients) between 2012 and 2016. A standardized questionnaire was used to collect information on self-reported and clinical variables. RESULTS: Within two years of primary treatment, 72% of ovarian, 64% of uterine, and 66% of cervical cancer patients were diagnosed with first recurrence, and 54, 67, and 72%, respectively, had symptomatic recurrence. Of symptomatic patients, 25-50% failed to make an appointment before their next scheduled follow-up visit. Computer tomography was the most common diagnostic procedure (89% of ovarian, 76% of uterine, and 62% of cervical cancer patients), and recurrence treatment in terms of chemotherapy was most frequently planned (86% of ovarian, 46% of uterine, and 62% of cervical cancer patients). CONCLUSIONS: A majority of patients experienced symptomatic recurrence, but many patients failed to make an appointment earlier than scheduled. Most first recurrences occurred within two years of primary treatment; the mean annual incidence rate for years 3-5 after primary treatment was <7%. New models for follow up of gynecological cancer patients could be considered.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofseriesActa Obstetricia et Gynecologica Scandinavica;96(10)
dc.rightsThis is the peer reviewed version of the following article: Vistad, I., Bjorge, L., Solheim, O., Fiane, B., Sachse, K., Tjugum, J., . . . Dorum, A. (2017). A national, prospective observational study of first recurrence after primary treatment for gynecological cancer in Norway. Acta Obstet Gynecol Scand, 96(10), 1162-1169. doi:10.1111/aogs.13199, which has been published in final form at http://dx.doi.org/10.1111/aogs.13199. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectVDP::Medisinske Fag: 700en
dc.subjectArtikkelen
dc.titleA national, prospective observational study of first recurrence after primary treatment for gynecological cancer in Norwayen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionacceptedVersionen
dc.identifier.doihttp://dx.doi.org/10.1111/aogs.13199
dc.identifier.cristinID1486511


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