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dc.contributor.authorAusland, Line
dc.contributor.authorRevheim, Mona-Elisabeth
dc.contributor.authorSkretting, Arne
dc.contributor.authorStokke, Caroline
dc.date.accessioned2017-10-05T11:01:40Z
dc.date.accessioned2017-10-17T12:28:32Z
dc.date.available2017-10-05T11:01:40Z
dc.date.available2017-10-17T12:28:32Z
dc.date.issued2017
dc.identifier.citationAusland, Revheim M, Skretting A, Stokke C. Respiratory motion during 90Yttrium PET contributes to underestimation of tumor dose and overestimation of normal liver tissue dose.. Acta Radiologica. 2017language
dc.identifier.urihttp://hdl.handle.net/10642/5307
dc.description.abstractBackground Yttrium-90 dosimetry after radioembolization is reliant on accurate quantitative imaging of the microsphere deposition. Previous studies have focused on the correction of geometrical resolution effects. Purpose To uncover additional effects of respiratory motion. Material and Methods Mathematical models describing spherical tumors were formed and two blurring effects, limited geometrical resolution and respiratory motion, were simulated. The virtual images were used as basis for dose volume histogram estimations by convolving the radioactivity representations with a dose point kernel. Results For respiratory motion only, the largest errors were found for the smallest tumors and/or tumors with heterogeneous distribution of yttrium-90 microspheres. The deviations in max dose and dose to 25% and 50% of the tumor volume were estimated at 20–40%, 10–30%, and 0–30%, respectively. Additional blurring from geometrical resolution increased the errors to 55–75%, 50–60%, and 25–60%, respectively. Conclusion Respiratory motion contributes to underestimation of tumor dose and overestimation of normal tissue dose.language
dc.language.isoenlanguage
dc.publisherSagelanguage
dc.subjectRespiratory motionlanguage
dc.subjectDosimetrylanguage
dc.subjectTumorslanguage
dc.titleRespiratory motion during 90Yttrium PET contributes to underestimation of tumor dose and overestimation of normal liver tissue dose.language
dc.typeJournal articlelanguage
dc.typePeer reviewedlanguage
dc.date.updated2017-10-05T11:01:40Z
dc.description.versionacceptedVersionlanguage
dc.identifier.doihttp://doi.org/10.1177/0284185117710052
dc.identifier.cristinID1490216
dc.source.issn0284-1851
dc.source.issn1600-0455
dc.relation.journalActa Radiologica


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