Now showing items 1-20 of 22

    • Two novel connexin32 mutations cause early onset X-linked Charcot-Marie-Tooth disease 

      Braathen, Geir Julius; Sand, Jette C.; Bukholm, Geir; Russell, Michael B. (BioMed Central, 2007-07-09)
      Background X-linked Charcot-Marie Tooth (CMT) is caused by mutations in the connexin32 gene that encodes a polypeptide which is arranged in hexameric array and form gap junctions. Methods We describe two novel ...
    • Physical distress is associated with cardiovascular events in a high 

      Einvik, Gunnar; Ekeberg, Øivind; Klemsdal, Tor O; Sandvik, Leiv; Hjerkinn, Elsa M (BioMed Central, 2009-03-30)
      Background: Self-reported health perceptions such as physical distress and quality of life are suggested independent predictors of mortality and morbidity in patients with established cardiovascular disease. This study ...
    • Cognitive deficits in chronic stroke patients: neuropsychological assessment, depression, and self-reports 

      Nakling, Arne; Årsland, Dag; Næss, Halvor; Wollschläger, Daniel; Fladby, Tormod; Hofstad, Håkon; Eike, Wehling (Karger, 2017)
      Background: Following stroke, clinicians are challenged to detect and untangle symptoms of cognitive dysfunction and mood disorders. Additionally, they need to evaluate the informative value of self-reports to identify ...
    • Overall Survival in Renal Cell Carcinoma after Introduction of Targeted Therapies: A Norwegian Population-Based Study 

      Beisland, Christian; Johannesen, Tom Bjørge; Klepp, Olbjørn; Axcrona, Ulrika; Torgersen, Knut Martin; Kowalski, Jan; Solli, Oddvar; Sandin, Rickard; Oldenburg, Jan (Dove Medical Press, 2017-01-16)
      Background: This population-wide retrospective, non-interventional registry study assessed changes in overall survival (OS) and factors influencing OS in Norwegian patients with renal cell carcinoma (RCC). Methods: Two ...
    • Subjective cognitive impairment is a predominantly benign condition in memory clinic patients followed for 6 years: The Gothenburg-oslo MCI Study 

      Hessen, Erik; Eckerström, Marie; Nordlund, Arto; Almdahl, Ina; Stålhammar, Jacob; Bjerke, Maria; Eckerström, Carl; Göthlin, Mattias; Fladby, Tormod; Reinvang, Ivar; Wallin, Anders (Karger, 2017-02-02)
      Background/Aims: In the quest for prevention or treatment, there is a need to find early markers for preclinical dementia. This study observed memory clinic patients with subjective cognitive impairment (SCI) and normal ...
    • Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study 

      Blach, Sarah; Zeuzem, Stefan; Manns, Michael; Altraif, Ibrahim; Duberg, Ann-Sofi; Muljono, David H; Waked, Imam; Alavian, Seyed M; Lee, Mei-Hsuan; Negro, Francesco; Abaalkhail, Faisal; Abdou, Ahmed; Abdulla, Maheeba; Rached, Antoine Abou; Aho, Inka; Akarca, Ulus; Ghazzawi, Imad Al; Kaabi, Saad Al; Lawati, Faryal Al; Namaani, Khalid Al; Serkal, Youssif Al; Al-Busafi, Said A; Al-Dabal, Layla; Aleman, Soo; Alghamdi, Abdullah S; Aljumah, Abdulrahman A; Al-Romaihi, Hamad E; Andersson, Monique I; Arendt, Vic; Arkkila, Perttu; Assiri, Abdullah M; Baatarkhuu, Oidov; Bane, Abate; Ben-Ari, Ziv; Bergin, Colm; Bessone, Fernando; Bihl, Florian; Bizri, Abdul R; Blachier, Martin; Blasco, Antonio J; Mello, Carlos E Brandao; Bruggmann, Philip; Brunton, Cheryl R; Calinas, Filipe; Chan, Henry L Y; Chaudhry, Asad; Cheinquer, Hugo; Chen, Chien-Jen; Chien, Rong-Nan; Choi, Moon Seok; Christensen, Peer B; Chuang, Wan-Long; Chulanov, Vladimir; Cisneros, Laura; Clausen, Mette R; Cramp, Matthew E; Craxi, Antonio; Croes, Esther A; Dalgard, Olav (Elsevier, 2017-03)
      Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral ...
    • Morbidity outcomes after surgical aortic valve replacement 

      Auensen, Andreas; Hussain, Amjad Iqbal; Bendz, Bjørn; Aaberge, Lars; Falk, Ragnhild Sørum; Hansen, Marte; Bye, Eva; Andreassen, Johanna; Beitnes, Jan Otto; Rein, Kjell Arne; Pettersen, Kjell I; Gullestad, Lars (BMJ Publishing Group, 2017-04-13)
      Objective In patients with mild to moderate operative risk, surgical aortic valve replacement (SAVR) is still the preferred treatment for patients with severe symptomatic aortic stenosis (AS). Aiming to broaden the knowledge ...
    • Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study 

      Pihlstrøm, Hege; Gatti, Francesca; Hammarström, Clara Louise; Eide, Ivar Anders; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Svensson, My Hanna Sofia; Midtvedt, Karsten; Mjøen, Geir; Dahle, Dag Olav; Hartmann, Anders; Holdaas, Hallvard (Wiley, 2017-04-24)
      In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and ...
    • Adherence to response-guided pegylated interferon and ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: The ACTIVATE study 

      Cunningham, Evan B; Hajarizadeh, Behzad; Dalgard, Olav; Amin, Janaki; Hellard, Margaret; Foster, Graham R; Bruggmann, Philip; Conway, Brian; Backmund, Markus; Robaeys, Geert; Swan, Tracy; Marks, Philippa S; Quiene, Sophie; Applegate, Tanya L; Weltman, Martin; Shaw, David; Dunlop, Adrian; Bruneau, Julie; Midgard, Håvard; Bourgeois, Stefan; Thurnheer, Maria Christine; Dore, Gregory J; Grebely, Jason; Shaw, Ineke; Siriragavan, Sharmila; Horschik, Tina; Sharma, Shawn; Eevers, Anita; Andreassen, Jessica; Melkeraaen, Ingunn; Widder, Nicole; Lesneuck, Kristof; Kotsoros, Barbara; Hazelwood, Susan; Holland, Rohan; Axten, David; Von Bibra, Sally; Powis, Jeff; Mason, Kate; Ryder, Stephen; Jack, Kate; Scheidegger, Claude; Huber, Christine; Ferguson, Catherine; Staehelin, Cornelia; Lacalamita, Melanie; Fragomeli, Vincenzo; Sevehon, Alison (BMC Springer, 2017-06-13)
      Background The aims of this analysis were to investigate treatment completion and adherence among people with ongoing injecting drug use or receiving opioid substitution therapy (OST) in a study of response-guided therapy ...
    • Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections - a Scandinavian real-life study 

      Dalgard, Olav; Weiland, Ola; Noraberg, Geir; Karlsen, Lars Normann; Heggelund, Lars; Färkkilä, Martti; Balselv, Ulla; Berlard, Erika; Øvrehus, Anne; Kjær, Mette Skalshøi; Krarup, Henrik; Røge, Birgit Thorup; Hallager, Sofie; Madsen, Lone G; Laursen, Alex Lund; Lagging, Martin; Weis, Nina (PLOS, 2017-07-13)
      Background and aims Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based ...
    • Biomarkers in subtypes of mild cognitive impairment and subjective cognitive decline 

      Eliassen, Carl F Andestad; Reinvang, Ivar; Selnes, Per; Grambaite, Ramune; Fladby, Tormod; Hessen, Erik (Wiley, 2017-07-28)
      Objectives Preclinical Alzheimers disease (AD) patients may or may not show cognitive impairment on testing. AD biomarkers are central to the identification of those at low, intermediate, or high risk of later dementia ...
    • Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD 

      Skjørten, Ingunn; Hilde, Janne Mykland; Melsom, Morten Nissen; Hisdal, Jonny; Hansteen, Viggo; Steine, Kjetil; Humerfelt, Sjur (Dove Medical Press, 2017-08-26)
      Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary ...
    • Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma 

      Pilskog, Martin; Beisland, Christian; Akslen, Lars A; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn (BMC Springer, 2017-08-31)
      Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical ...
    • Extending XNAT platform with an incremental semantic framework 

      Reina, Santiago Timon; Rincón, Mariano; Martinez-Tomás, Rafael (Frontiers Media S.A., 2017-08-31)
      Informatics increases the yield from neuroscience due to improved data. Data sharing and accessibility enable joint efforts between different research groups, as well as replication studies, pivotal for progress in the ...
    • Impaired synaptic function is linked to cognition in Parkinson's disease 

      Selnes, Per; Stav, Ane Løvli; Johansen, Krisztina Kunszt; Bjørnerud, Atle; Coello, Sebastien Christopher; Auning, Eirik; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Hessen, Erik; Zetterberg, Henrik; Blennow, Kaj; Årsland, Dag; Fladby, Tormod (Wiley, 2017-08-31)
      Objective Cognitive impairment is frequent in Parkinson's disease, but the underlying mechanisms are insufficiently understood. Because cortical metabolism is reduced in Parkinson's disease and closely associated with ...
    • Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs. 

      Grebely, Jason; Bruneau, Julie; Lazarus, Jeffrey; Dalgard, Olav; Bruggmann, Philip; Treloar, Carla; Hickman, Matthew; Hellard, Margaret; Roberts, Teri; Crooks, Levinia; Midgard, Håvard; Larney, Sarah; Degenhardt, Louisa; Alho, Hannu; Byrne, Jude; Dillon, John F; Feld, Jordan J; Foster, Graham; Goldberg, David E; Lloyd, Andrew R; Reimer, Jens; Robaeys, Geert; Torrens, Marta; Wright, Nat; Maremmani, Icro; Norton, Brianna L; Litwin, Alain H; Dore, Gregory J (Elsevier, 2017-09)
      Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but ...
    • Efficacy of response-guided directly observed pegylated interferon and self-administered ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: The ACTIVATE study 

      Grebely, Jason; Dalgard, Olav; Cunningham, Evan B; Hajarizadeh, Behzad; Foster, Graham R; Bruggmann, Philip; Conway, Brian; Backmund, Markus; Robaeys, Geert; Swan, Tracy; Amin, Janaki; Marks, Philippa S; Quiene, Sophie; Applegate, Tanya L; Weltman, Martin; Shaw, David; Dunlop, Adrian; Hellard, Margaret; Bruneau, Julie; Midgard, Håvard; Bourgeois, Stefan; Staehelin, Cornelia; Dore, Gregory J (Elsevier, 2017-09)
      Background There are few data on treatment for hepatitis C virus (HCV) infection among people with ongoing injecting drug use. This study evaluated the efficacy of response-guided therapy for chronic HCV genotypes 2/3 ...
    • Bone turnover markers are associated with bone density, but not with fracture in end stage kidney disease: a cross-sectional study 

      Jørgensen, Hanne Skou; Winther, Simon; Bøttcher, Morten; Hauge, Ellen Margrethe; Rejnmark, Lars; Svensson, My Hanna Sofie; Ivarsen, Per (BMC Springer, 2017-09-06)
      Background Fracture risk is increased in chronic kidney disease (CKD), but assessment of bone fragility remains controversial in these patients. This study investigated the associations between bone turnover markers, bone ...
    • An update on cladribine for relapsing-remitting multiple sclerosis 

      Holmøy, Trygve; Torkildsen, Øivind Fredvik; Myhr, Kjell-Morten (Taylor & Francis, 2017-09-11)
      INTRODUCTION: Despite recent progress, currently available therapies for relapsing remitting multiple sclerosis (MS) are only partly effective, and their use is limited by tolerability and safety issues, as well as high ...
    • Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification 

      Rutkovskiy, Arkady; Malashicheva, Anna; Sullivan, Gareth; Bogdanova, Mariia; Kostareva, Anna; Stensløkken, Kåre-Olav; Fiane, Arnt E; Vaage, Ingvar Jarle (Wiley, 2017-09-22)
      Aortic valve stenosis due to calcification of the valve leaflets is the most common valve disease in the developed world. It is the third leading cause of cardiovascular disease.1 Risk factors include male gender, smoking, ...