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dc.contributor.authorBølling, Anette Ken_US
dc.contributor.authorTotlandsdal, Annike Ien_US
dc.contributor.authorSallsten, Gerden_US
dc.contributor.authorBraun, Arturen_US
dc.contributor.authorWesterholm, Rogeren_US
dc.contributor.authorBergvall, Christofferen_US
dc.contributor.authorBoman, Johanen_US
dc.contributor.authorDahlman, Hans Jen_US
dc.contributor.authorSehlstedt, Mariaen_US
dc.contributor.authorCassee, Flemmingen_US
dc.contributor.authorSandstrom, Thomasen_US
dc.contributor.authorSchwarze, Per Een_US
dc.contributor.authorHerseth, Jan Ien_US
dc.date.accessioned2013-04-05T11:12:21Z
dc.date.available2013-04-05T11:12:21Z
dc.date.issued2012-11-23en_US
dc.identifier.citationBølling, A. K., Totlandsdal, A. I., Sallsten, G., Braun, A., Westerholm, R., Bergvall, C., Boman, J., Dahlman, H.J., Sehlstedt, M., Cassee, F., Sandstrom, T., Schwarze, P. E., Herseth, J. I. (2012). Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines. Particle and Fibre Toxicology, 9:45, -15.en_US
dc.identifier.issn1743-8977en_US
dc.identifier.otherFRIDAID 965868en_US
dc.identifier.urihttp://hdl.handle.net/10642/1428
dc.description.abstractBackground Exposure to particulate matter (PM) has been linked to several adverse cardiopulmonary effects, probably via biological mechanisms involving inflammation. The pro-inflammatory potential of PM depends on the particles’ physical and chemical characteristics, which again depend on the emitting source. Wood combustion is a major source of ambient air pollution in Northern countries during the winter season. The overall aim of this study was therefore to investigate cellular responses to wood smoke particles (WSPs) collected from different phases of the combustion cycle, and from combustion at different temperatures. Results WSPs from different phases of the combustion cycle induced very similar effects on pro-inflammatory mediator release, cytotoxicity and cell number, whereas WSPs from medium-temperature combustion were more cytotoxic than WSPs from high-temperature incomplete combustion. Furthermore, comparisons of effects induced by native WSPs with the corresponding organic extracts and washed particles revealed that the organic fraction was the most important determinant for the WSP-induced effects. However, the responses induced by the organic fraction could generally not be linked to the content of the measured polycyclic aromatic hydrocarbons (PAHs), suggesting that also other organic compounds were involved. Conclusion The toxicity of WSPs seems to a large extent to be determined by stove type and combustion conditions, rather than the phase of the combustion cycle. Notably, this toxicity seems to strongly depend on the organic fraction, and it is probably associated with organic components other than the commonly measured unsubstituted PAHs.en_US
dc.language.isoengen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofseriesParticle and Fibre Toxicology;9:45en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Toksikologi: 730en_US
dc.subjectParticulate matteren_US
dc.subjectInflammationen_US
dc.subjectWood smokeen_US
dc.subjectCombustion phaseen_US
dc.subjectCombustion temperatureen_US
dc.subjectOrganic fractionen_US
dc.titleWood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell linesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.version© 2012 Bølling et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.identifier.fulltextfulltext https://oda.hio.no/jspui/bitstream/10642/1428/1/965868.pdf
dc.identifier.doihttp://dx.doi.org/10.1186/1743-8977-9-45


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